Patients with Chronic Granulomatous Disease (CGD) are susceptible to infections by catalase-positive organisms. This is because CGD patients have a deficiency in their neutrophils' ability to kill bacteria, particularly those that can break down their own hydrogen peroxide using catalase.
Los pacientes con Granulomatosis Crónica (CGD) tienen un sistema inmunológico deficiente que los hace susceptibles a infecciones por ciertos organismos. Específicamente, son susceptibles a organismos catalasa positivos. Esto se debe a que la mieloperoxidasa, una enzima en los neutrófilos, utiliza peróxido de hidrógeno (H2O2) para matar bacterias. Si las bacterias producen catalasa, descomponen su propio H2O2, lo que impide que la mieloperoxidasa produzca ácido hipocloroso (lejía) para matarlas.
| Front | CGD patients are susceptible to what organisms? |
|---|---|
| Back | Catalase (+) organisms → bacteria excrete H2O2 into cell environment → myeloperoxidase can convert this bacterial H2O2 → HOCL- (bleach) to KILL bacteria → however, many bacteria have their own catalase, which breask down their own H2O2 so that there is not enough H2O2 to convert into HOCL- (bleach) |
Tags: microbiology
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