This note identifies three viruses associated with cancer: Hepatitis B Virus (HBV), Human Papillomavirus (HPV), and Epstein-Barr Virus (EBV). It details their mechanisms, such as HBV's link to HCC and HPV's E6/E7 proteins affecting p53 and Rb, leading to cervical cancer, and EBV's association with Burkitt lymphoma and nasopharyngeal carcinoma.
Tres virus asociados con el cáncer son el Virus de la Hepatitis B (VHB), el Virus del Papiloma Humano (VPH) y el Virus de Epstein-Barr (VEB). El VHB está fuertemente asociado con el carcinoma hepatocelular (CHC). El VPH produce las proteínas virales E6 (que degrada Rb) y E7 (que degrada p53), lo que conduce a la proliferación celular y al cáncer de cuello uterino. El VEB está asociado con el linfoma de Burkitt y el carcinoma nasofaríngeo.
| Front | (3) viruses associated with cancer → associated mechanisms? |
|---|---|
| Back | ALL cancer-causing viruses are DNA viruses (except HCV) → HBV | HPV | EBV → cell proliferation with excess DNA nucleotide synthesis in S phase → HBV has strong association with HCC HPV produces E6 viral protein which ↓Rb and E7 viral protein which ↓p53, which kicks cell cycle into overdrive and leads to overproliferation | overgrowth of epithelial cells, dysplasia, and ultimately cervical cancer EBV is associated with Burkitt lymphoma (B-lymphocyte lymphoma), which manifests as B cell proliferation, and Nasopharyngeal carcinoma. The t(8;14) translocation is consistently associated with Burkitt lymphoma, but this translocation alone is not found in nasopharyngeal carcinoma. ↓ Burkitt lymphoma Nasopharyngeal carcinoma Oral hairy leukoplakia |
Tags: microbiology
Learn with these flashcards. Click next, previous, or up to navigate to more flashcards for this subject.
Next card: H o bacteria catalase convert hocl bleach cgd
Previous card: S n b h catalase organisms cat eed
Up to card list: Microbiology 101 → Step 1 USMLE