The major virulence factor of Hib (Haemophilus influenzae type B) is IgA protease; its vaccine needs to be conjugated to proteins to facilitate T-cell activation for B-cell isotype switching, leading to antibody production beyond IgM.
Hib'in (Haemophilus influenzae tip B) ana virülans faktörü IgA proteazıdır, konjüge aşılar ise T hücre aktivasyonu ile B hücre izotip geçişini sağlayarak IgM dışındaki antikorların üretimine yol açar.
| Front | Major virulence factor of Hib (Hemophilus influenza B) Why does it need to be conjugated to a protein? |
|---|---|
| Back | IgA protease → Hib vaccine conjugated to proteins so T cells can be activated to induce B cell isotype switching → leads to production of antibodies other than IgM |
Tags: microbiology
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