Question

HIV-1 Protease Inhibitors How does they affect lipid metabolism?What adverse effects do they exhibit?

Accepted Answer

They cause lipodystrophy by decreased hepatic chylomicron uptake and TG clearance while a drug-induced body fat redistribution (from extremities to abdominal viscera, subcutaneous adipose tissues of thorax, posterior neck aka "buffalo hump", supraclavicular regions) causes a cushing-like syndrome

Front	HIV-1 Protease Inhibitors How does they affect lipid metabolism? What adverse effects do they exhibit?
Back	They cause lipodystrophy by decreased hepatic chylomicron uptake and TG clearance while a drug-induced body fat redistribution (from extremities to abdominal viscera, subcutaneous adipose tissues of thorax, posterior neck aka "buffalo hump", supraclavicular regions) causes a cushing-like syndrome

Hiv 1 Protease Inhibitors Affect Lipid Metabolism Adverse Effects