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Microbiology 101 → Step 1 USMLE

Hiv 1 Protease Inhibitors  Affect Lipid Metabolism Adverse Effects

HIV-1 Protease Inhibitors can cause lipodystrophy, characterized by fat redistribution (e.g., "buffalo hump"), due to decreased hepatic chylomicron uptake and TG clearance, potentially leading to a cushing-like syndrome.

HIV-1 Proteaz İnhibitörleri, düşük hepatik şilomikron alımı ve TG klirensi nedeniyle lipodistrofiye (örn. "buffalo hump") ve Cushing benzeri sendroma yol açabilir.

Front HIV-1 Protease Inhibitors 

How does they affect lipid metabolism?
What adverse effects do they exhibit? 
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They cause lipodystrophy by decreased hepatic chylomicron uptake and TG clearance while a drug-induced body fat redistribution (from extremities to abdominal viscera, subcutaneous adipose tissues of thorax, posterior neck aka "buffalo hump", supraclavicular regions) causes a cushing-like syndrome

Tags: antiviral, drugs

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