Question

What HIV therapy drugs works by blocking actions of HIV-1 protease and preventing assembly of HIV products in the new virion?

Accepted Answer

Protease inhibitors (saquinavir); protease is an HIV-encoded enzyme responsible for cleaving the initial pol and gag polypeptides into their final products.The env gene product also undergoes posttranslational cleavage. However, a host-encoded enzyme, not HIV protease, mediates this cleavage.

Front	What HIV therapy drugs works by blocking actions of HIV-1 protease and preventing assembly of HIV products in the new virion?
Back	Protease inhibitors (saquinavir); protease is an HIV-encoded enzyme responsible for cleaving the initial pol and gag polypeptides into their final products.The env gene product also undergoes posttranslational cleavage. However, a host-encoded enzyme, not HIV protease, mediates this cleavage.

Hiv Protease Cleavage Therapy Drugs Works Blocking Actions