Apedia

Reverse Transcriptase Inhibitors Directly Work Binding Enzyme Nnrtis 

NNRTIs, such as nevirapine, directly inhibit HIV reverse transcriptase by binding to the enzyme's catalytic site, thereby blocking the conversion of viral RNA to DNA.

NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitors) like nevirapine directly bind to the reverse transcriptase enzyme to block its catalytic site, preventing HIV RNA to dsDNA conversion.

Front What reverse transcriptase inhibitors work by directly binding the reverse transcriptase enzyme?
Back

NNRTIs → original genetic information from HIV is in the form of RNA and reverse transcriptase is needed to convert ssRNA to dsDNA → two classes of reverse transcriptase inhibitors → Non-Nucleoside Reverse Transcriptase Inhibitors (nevirapine) which bind enzyme directly to block catalytic site → Nucleoside analogue Reverse Transcriptase Inhibitors (zidovudine) which are incorporated into DNA strand to prevent elongation


Tags: antiviral, drugs

Learn with these flashcards. Click next, previous, or up to navigate to more flashcards for this subject.

Next card: Hiv protease cleavage therapy drugs works blocking actions

Previous card: Reverse transcriptase inhibitors work inhibiting nucleotide binding nrtis

Up to card list: Microbiology 101 → Step 1 USMLE