Flucytosine inhibits fungal DNA and RNA synthesis by converting to 5-FU, which then inhibits thymidylate synthase. It is used for systemic Candida infections and cryptococcal meningitis (with amphotericin B).
Flucitozin inhibira sintezu gljivične DNK i RNK, pretvarajući se u 5-FU, koji zauzvrat inhibira timirilat sintazu. Koristi se za sistemske infekcije kandide i kriptokokni meningitis (sa amfotericinom B).
| Front | MOA of Flucytosine → (2) uses |
|---|---|
| Back | Inhibits fungal DNA | RNA synthesis → converted to 5-FU by cytosine deaminase → 5-FU converted to 5-FdUMP which inhibits thymidylate synthase, an essential enzyme need to make dTMP (thymydilate acid), an essential component of DNA synthesis Uses ↓ Systemic candida infections Cryptococcal meningitis (Flucytosine + Amphotericin) |
Tags: antifungal, drugs
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