Question

MOA of Flucytosine → (2) uses

Accepted Answer

Inhibits fungal DNA | RNA synthesis → converted to 5-FU by cytosine deaminase → 5-FU converted to 5-FdUMP which inhibits thymidylate synthase, an essential enzyme need to make dTMP (thymydilate acid), an essential component of DNA synthesis

Uses

↓

Systemic candida infections

Cryptococcal meningitis

(Flucytosine + Amphotericin)

Front	MOA of Flucytosine → (2) uses
Back	Inhibits fungal DNA \| RNA synthesis → converted to 5-FU by cytosine deaminase → 5-FU converted to 5-FdUMP which inhibits thymidylate synthase, an essential enzyme need to make dTMP (thymydilate acid), an essential component of DNA synthesis Uses ↓ Systemic candida infections Cryptococcal meningitis (Flucytosine + Amphotericin)

Inhibits Dna Synthesis Converted 5 Fu Essential Moa Of