The Salk vaccine (IPV) uses killed virus and is given IM, while the Sabin vaccine (OPV) uses live attenuated virus, administered orally, inducing mucosal IgA to block transmission; however, the Sabin vaccine can revert to virulent forms.
Salk (IPV) aşısı ölü virüs içerir ve IM yolla uygulanır, Sabin (OPV) aşısı ise canlı zayıflatılmış virüs içerir, oral yolla verilir ve mukozal IgA yanıtı ile bulaşıcı engeller; Sabin aşısı virülansına geri dönebilir.
| Front | Salk® vs. Sabin® polio vaccines What are the major differences? |
|---|---|
| Back | Killed viral vaccines Inactivated Polio Vaccine (IPV) IM injection Require booster vs. Sabin® Live attenuated vaccine Oral Polio Vaccine (OPV) ↑mucosal IgA interrupts mucosal transmission (feco-oral route) Better immune response (humoral|CMI) Can revert back to wild type virus Requires no booster |
Tags: microbiology
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