Question

What is the MOA of PCV13 vaccine?

Accepted Answer

PCV13 is a conjugate vaccine↓13 serotypes of S.pneumoniae covalently attached to inactivated diphtheria toxin (protein)↓B-cells endocytose polysaccharide-protein-conjugate vaccine and display protein component of vaccine on MHCII↓T-cell receptor activated by the same protein↓T-cell activation induces strong immune response↓T-cell-mediated B-lymphocyte activation generates higher-affinity antibodies and memory cells↓T-cell-mediated B-lymphocyte activation also enables class switching↓Formation of IgA mucosal antibodies which can reduce bacterial colonization rates

Vaccine Activation Protein T Cell T Cell Mediated B Lymphocyte Antibodies Moa