The PCV13 vaccine is a conjugate vaccine linking 13 S. pneumoniae serotypes to an inactivated diphtheria toxin (protein), inducing a robust T-cell-dependent immune response that generates memory cells and IgA.
PCV13-rokote on konjugaattirokote, joka yhdistää 13 S. pneumoniae -tyyppiä inaktivoituun kurkkumätätoksiiniin (proteiini) ja stimuloi voimakasta, T-soluvälitteistä immuunivastetta, joka tuottaa muistisoluja ja IgA:ta.
| Front | What is the MOA of PCV13 vaccine? |
|---|---|
| Back | PCV13 is a conjugate vaccine ↓ 13 serotypes of S.pneumoniae covalently attached to inactivated diphtheria toxin (protein) ↓ B-cells endocytose polysaccharide-protein-conjugate vaccine and display protein component of vaccine on MHCII ↓ T-cell receptor activated by the same protein ↓ T-cell activation induces strong immune response ↓ T-cell-mediated B-lymphocyte activation generates higher-affinity antibodies and memory cells ↓ T-cell-mediated B-lymphocyte activation also enables class switching ↓ Formation of IgA mucosal antibodies which can reduce bacterial colonization rates |
Tags: microbiology
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