Common irreversible non-competitive inhibitors are cyanides, binding to heme iron in cytochromes, and heavy metal ions (Hg, Ag, Cu), which denature enzymes by binding to thiol groups.
Irreversible non-competitive inhibitors include cyanides (which bind to iron in cytochromes) and heavy metal ions like Hg, Ag, and Cu (which bind to thiol groups and denature enzymes).
| Front | Mode of action of common Irreversible Non-competitive inhibitors (NAME THEM) |
|---|---|
| Back | 1) Cyanides: combine with Fe in prosthetic groups of Cytochrome oxidases. 2) Heavy Metal Ions: Hg, Ag, Cu combine with thiol group of enzyme and break the disulphide bridges. The enzyme becomes denatured. |
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