Slight pH changes can temporarily inactivate enzymes by altering enzyme and substrate ionization, while extreme changes cause denaturation by breaking ionic bonds.
Einfluss von pH auf die Enzymaktivität: Eine leichte Änderung des pH-Wertes: Verursacht Ionisation von Aminosäuren des Enzyms, daher wird das Enzym *temporär* inaktiv. Beeinflusst auch die Ionisation des Substrats. Extreme Änderungen führen zum Abbau von *Ionenbindungen* und zur *Denaturierung* von Proteinen.
| Front | Effect of pH on enzyme activity |
|---|---|
| Back | A slight change in pH: • Causes ionization of amino acids of enzyme, so enzyme becomes inactive temporarily. • Also affects ionization of substrate. Extreme changes cause *ionic* bond-breakage and denaturation of proteins. |
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