Insulin secretion is triggered by increased blood glucose, leading to ATP production, K+ channel closure, membrane depolarization, Ca+ channel opening, and subsequent insulin exocytosis.
A secreção de insulina é desencadeada pelo aumento da glicose no sangue, que leva à produção de ATP, fechamento de canais de K+, despolarização da membrana, abertura de canais de Ca+ e, consequentemente, à exocitose de insulina.
| Front | How is insulin secreted? |
|---|---|
| Back | - Beta cell membrane at resting potential when normal blood glucose conc - when high blood glucose levels, glucose moves into cell via glucose transporters and its metabolised into ATP in mito (via glycolysis pathway) - ATP binds to ATP-sensitive K+ channels (closing them) and therefore leads to depolaristaion of membrane as K+ accumalates in cell - VG-Ca+ channels open so Ca+ enters and causes secretory vesicles to travel to cell surface membrane where it releases insulin via exocytosis |
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