| Front | How is insulin secreted? |
|---|---|
| Back | - Beta cell membrane at resting potential when normal blood glucose conc - when high blood glucose levels, glucose moves into cell via glucose transporters and its metabolised into ATP in mito (via glycolysis pathway) - ATP binds to ATP-sensitive K+ channels (closing them) and therefore leads to depolaristaion of membrane as K+ accumalates in cell - VG-Ca+ channels open so Ca+ enters and causes secretory vesicles to travel to cell surface membrane where it releases insulin via exocytosis |
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