Pathogens Specific Phagocytes Antigens Defences Rid Temp Stimulate

non specific defences (rid of pathogens)

- fever (normal body temp maintained by hypothalamus, when pathogens invade, cytokines stimulate hypo to reset thermostat and temp higher so that;

 - pathogens repro inhibited and specific immune sytsem works faster

 - phagocytes are WBCs that engulf and destroy pathogens, 2 types (neutrophils and macrophages), phago build up at site of infection and attack pathogens

 phagocytosis;- pathogens produce chemicals attracting phagocytes

  - phagocytes recognise non self proteins on pathogens (not specific)

  - phagocyte engulfs pathogen and enclose in vacuole (phagosome)

  - phagosome combines with lysosome to form pagolysosome, enzymes from lysosome digest/destroy pathogen

- pus consists of dead neutrophils and pathogens

- neutrophils take less than 10 mins while macrophages take longer 

- when macrophage digests pathogen, it combines antigens from pathogen with glycoproteins called major histocompatability complex, MHC moves antigens to macrophages surface, becoming an antigen presenting cell, antigens now stimulate other cells involved in specific immune response