In a synapse, an action potential reaching the presynaptic terminal opens calcium channels, causing Ca2+ influx and neurotransmitter release. The neurotransmitter diffuses across the synaptic cleft, binds to receptors, opens Na+ channels, and triggers an action potential in the postsynaptic neuron.
في المشبك، يفتح وصول جهد الفعل إلى الطرف قبل المشبكي قنوات الكالسيوم، مما يسمح بدخولها وتحرير الناقل العصبي. ينتشر الناقل العصبي عبر الشق المشبكي ويرتبط بالمستقبلات، مما يفتح قنوات الصوديوم ويسبب جهد فعل في العصبون بعد المشبكي.
| Front | synoptic transmission |
|---|---|
| Back | synoptic transmission - AP reaches end of presynopyic membrane which is depolarised, which causes Ca2+ channels to open and Ca2+ to diffuse into synoptic knob and vesicles to fuse with presynoptic membrane and release contents (NT) via exocytisis into synoptic cleft - NT diffuses towards postsynoptic neurone where it binds to NT receptor, which causes Na+ channels to open and Na+ enter postsynoptic neurone and causes AP which is propogated along neurone |
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