Ophthalmic Knowledge for Residents: Pathology

Cells Classic Histologic Appearance Retinoblastoma Round Oval Nuclei

Front	What is the classic histologic appearance of retinoblastoma?
Back	● Cells with round or oval nuclei, approximately twice the size of a lymphocyte; high mitotic activity; necrosis, calcification, and pseudorosettes consisting of viable tumor cells (asterisk) surrounding a blood vessel (arrow); Flexner-Wintersteiner rosettes (central lumen lined by refractile structure corresponding to ELM); fleurettes (differentiated photoreceptors)

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