Ophthalmic Knowledge for Residents: Pathology

Chrpe Solitary Demarcated Flat Darkly Pigmented Subretinal Plaque

Front	What is a CHRPE?
Back	● Solitary, well demarcated, flat darkly pigmented subretinal plaque ● Usually between 1-19 mm ● Non-hereditary and sporadic ● Areas of depigmentation = lacuna ● Mild growth can be seen ● Cells are taller than normal RPE ● Densely packed with large, spherical melanin pigment granules ● Hyperplasia and hypertrophy

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