Ophthalmic Knowledge for Residents: Pathology

Hyperpigmentation White Ocular Melanocytosis Oculodermal Melanocytosis Nevus Ota

Front

What is ocular melanocytosis (oculodermal melanocytosis, nevus of ota) and what is the epidemiology and genetic associations?

Back

● Hyperpigmentation of the episclera and uvea ● Histology shows increased dendritic melanocytes in the episclera, sclera, and dermal layers of the skin ● Associated with cutaneous hyperpigmentation along CN V ● Common in Asian and African Americans ● In white populations it increases the risk of uveal melanoma to 1:400 (from 1:13,000 in general white population) ● Associated with hyperpigmentation of the iris and choroid ● Mutation in GNAQ and GNA11

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