Question

In the Collaborative Ocular Melanoma (COM) Trial, what is the definition of a large choroidal melanoma? What were they studying in large melanomas? What were the results?

Accepted Answer

● Large choroidal melanoma:
○ > 16 mm basal diameter
○ > 10 mm apical height
● Compared enucleation alone vs external beam
radiotherapy followed by enucleation
● Findings:
○ Adjunctive radiotherapy did not impact
overall survival
○ Primary enucleation alone is sufficient to
manage large melanomas

Front	In the Collaborative Ocular Melanoma (COM) Trial, what is the definition of a large choroidal melanoma? What were they studying in large melanomas? What were the results?
Back	● Large choroidal melanoma: ○ > 16 mm basal diameter ○ > 10 mm apical height ● Compared enucleation alone vs external beam radiotherapy followed by enucleation ● Findings: ○ Adjunctive radiotherapy did not impact overall survival ○ Primary enucleation alone is sufficient to manage large melanomas

Large Enucleation Choroidal Mm Radiotherapy Collaborative Ocular Melanoma