Ophthalmic Knowledge for Residents: Pathology

Melanomas Risk Iris Light Epidemiology Factors Histology Indications

Front

What is the epidemiology, risk factors, histology, and indications for treatment/excision of iris melanomas?

Back

● Iris melanomas make up 3-5%% of all uveal melanomas ● Low mortality: 1-4% ● Risk factors: ○ Light skin, light iris, oculodermal melanocytosis in daily pigmented patents ● Most are spindle cell melanomas, unlike choroidal melanomas which are mostly mixed ● Can cause extrascleral extension and seeding/secondary glaucoma which can be treated with local radiation or enucleation ● Indication for excision is growth involving the angle/TM up to 3-4 clock hours

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