Question

What is the most common cell origin for optic nerve glioma? What is the histologic appearance of an optic nerve glioma? What are optic nerve gliomas associated with? What is the typical prognosis? What are the treatment options?

Accepted Answer

● Pilocytic astrocyte
● Histology shows Rosenthal fibers (enlarged, deeply
eosinophilic filaments)
● Associated with neurofibromatosis type 1
● Slow growing, with long term survival
● Typically observed unless progressive visual loss or
growth more posterior into the CNS
● Treatment of gliomas itself can result in vision loss
in the affected eye

Front	What is the most common cell origin for optic nerve glioma? What is the histologic appearance of an optic nerve glioma? What are optic nerve gliomas associated with? What is the typical prognosis? What are the treatment options?
Back	● Pilocytic astrocyte ● Histology shows Rosenthal fibers (enlarged, deeply eosinophilic filaments) ● Associated with neurofibromatosis type 1 ● Slow growing, with long term survival ● Typically observed unless progressive visual loss or growth more posterior into the CNS ● Treatment of gliomas itself can result in vision loss in the affected eye

Optic Nerve Glioma Treatment Loss Common Cell Origin