Question

What do Touton giant cells look like on pathology and what conditions are they seen in?

Accepted Answer

● Ring of nuclei that are surrounded by foamy ring of
lipid
● Seen in xanthogranulomatous disease
○ Juvenile X-linked xanthogranuloma
○ Adult onset xanthogranuloma
○ Adult onset asthma
○ Periocular xanthogranuloma
○ Necrobiotic xanthogranuloma
○ Erdheim Chester Disease

Front	What do Touton giant cells look like on pathology and what conditions are they seen in?
Back	● Ring of nuclei that are surrounded by foamy ring of lipid ● Seen in xanthogranulomatous disease ○ Juvenile X-linked xanthogranuloma ○ Adult onset xanthogranuloma ○ Adult onset asthma ○ Periocular xanthogranuloma ○ Necrobiotic xanthogranuloma ○ Erdheim Chester Disease

Xanthogranuloma Ring Disease Adult Onset Touton Giant Cells