Albumin decreases in concentration during inflammation as the liver reduces its production to balance positive APPs and maintain vascular colloidal pressure. Fibrinogen increases in concentration and is cleaved at the injury site to form fibrin for hemostasis.
Albumina (-): diminui em concentração na presença de inflamação. O fígado diminui sua produção de propósito. Existem tantos APs positivos, então a albumina neutraliza isso para que a pressão cólica na vasculatura não fique muito alta (equilíbrio). --> não queremos que a água seja atraída para o espaço vascular, então precisamos disso! Fibrinogênio (+): aumenta em concentração sanguínea em tempos de inflamação. Clivada no local da lesão --> o fibrinogênio é usado para hemostasia (coágulo primário).
| Front | Name the two APPs and describe their characteristics? |
|---|---|
| Back | Albumin (-): decreases in concentration in the present of inflammation. The liver decreases its production on purpose. There are so many positive APP's so albumin counteracts that so that colloidal pressure in vasculature doesn't get too high (balance things out) --> we don’t want water drawn into vascular space so we need this! Fibrinogen (+): increase in blood concentration in times of inflammation. Cleaved at injury site --> fibrin is used for hemostasis (primary clot) |
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