| Text | What genes are involved in the pathogenesis of Renal Cell Carcinoma: Loss of VHL (3p) tumor suppressor --> Causes INCREASED IGF-1, promoting growth --> Also INCREASED HIF transcription factor which stimulates Vascular Endothelial & Platelet Derived growth factors (VEGF & PDGF) |
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Tags: pathoma_ch.12_kidney_renal_neoplasia
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