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A-Level Biology OCR A

Allele Gene Cells Healthy Function Somatic Germ Line

This flashcard compares somatic and germ line gene therapy. Somatic therapy targets body cells, requiring many cells to be affected for temporary relief that is not passed to offspring and does not cure the genetic disease. Germ line therapy targets reproductive cells, needing fewer cells affected but is inherited by offspring, potentially curing the genetic disease.

This flashcard compares somatic and germ line gene therapy. Somatic therapy targets body cells, requires affecting many cells for temporary relief without inheritance, and doesn't cure the genetic disease. Germ line therapy targets egg, sperm, or early embryo cells, affecting fewer cells but is passed to offspring, potentially curing the genetic disease.

Front Compare somatic and germ line therapy.
Back
Somatic cell gene therapy
  • Replacement of mutant/faulty gene in body cells with healthy/normal allele
  • Must be done in many cells
  • Have to get healthy allele into nucleus of cells
  • Gene needs to function long-term
  • Healthy allele not passed onto offspring
  • Does not cure genetic disease





Germ line cell therapy
  • Replacement of mutant/faulty gene in egg/sperm/eraly embryo with healthy/normal allele
  • Only needs to be done in one or two cells but required for every child born to an affected individual
  • Have to get healthy allele into nucleus of cells
  • Gene needs to function long term
  • Healthy allele will function in individual and will be passed to their children
  • Cures genetic disease

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