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Enzyme Increasing Bonds Protein Structure Changed Shape Longer

Front Explain why increasing the temperature up from the optimum decreases the rate of reaction abruptly.
Back Increasing temp up from optimum:
  • At higher temp, bonds holding enzyme protein structure together vibrate more and eventually strain and break
  • Breaking of bonds result in change in the precise tertiary structure of the protein
  • Enzyme has changed shape - denatured
  • Active site has changed shape and is no longer complementary to substrate - substrate cant fit - enzyme is no longer a functional catalyst


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