Methylation of DNA in tumor suppressor gene promoters inhibits transcription factor binding and RNA polymerase activity, reducing the production of tumor suppressor proteins and leading to uncontrolled cell division and cancer.
- methylation of DNA in promoter - binding transcriptional factors inhibited - RNA polymerase not stimulated to transcribe gene - rate of transcription decreases - rate of translation decreases - tumour suppressor protein is not produced - uncontrolled cell division occurs
| Front | How does methylation of DNA in tumour suppressor genes lead to cancer? |
|---|---|
| Back | - methylation of DNA in promoter - binding transcriptional factors inhibited - RNA polymerase not stimulated to transcribe gene - rate of transcription decreases - rate of translation decreases - tumour suppressor protein is not produced - uncontrolled cell division occurs |
Tags: gene_expression
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