In asthmatics, re-exposure to an allergen triggers IgE-mediated mast cell activation, leading to the release of histamine and leukotrienes in the early phase, causing bronchoconstriction, inflammation, and edema.
Bei Asthmatikern führt die erneute Exposition gegenüber einem Allergen zu einer IgE-vermittelten Aktivierung von Mastzellen. In der frühen Phase dieser Reaktion kommt es zur Freisetzung von vorab gebildeten Histamingranula und zur Bildung von Leukotrienen C4, D4 und E4, die zu Bronchokonstriktion, Entzündung und Ödemen führen.
| Front | In asthmatic individuals, reexposure to an allergen leads to an IgE-mediated activation of mast cells. What occurs in the early phase of this reaction? |
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| Back | Release of preformed histamine granules and generation of leukotrienes C4, D4, and E4 lead to bronchoconstriction, inflammation, and edema. |
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