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Enzyme Substrate Conformational Change Formation Complex Specificity Active Site

The process of a normal enzyme reaction involves the formation of an enzyme-substrate complex according to enzyme-substrate specificity, where the active site undergoes conformational change for induced fit. This change destabilizes bonds in the substrate, lowering activation energy (Ea), allowing the substrate to be converted to product at an accelerated rate.

El proceso de una reacción enzimática normal implica la formación de un complejo enzima-sustrato según la especificidad enzima-sustrato, donde el sitio activo cambia de conformación para el encaje inducido. Este cambio desestabiliza los enlaces del sustrato, reduciendo la energía de activación (Ea), lo que permite que el sustrato se convierta en producto a una velocidad acelerada.

Original formation of enzyme-substrate complex according to enzyme-substrate specificity
active site undergoes conformational change upon binding for induced fit 
conformational change destabilizes bonds in substrate, lowering Ea
substrate is converted to product at accelerated rate 
Title process of a normal enzyme reaction
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formation of enzyme-substrate complex according to enzyme-substrate specificity
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formation of enzyme-substrate complex according to enzyme-substrate specificity
active site undergoes conformational change upon binding for induced fit 
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active site undergoes conformational change upon binding for induced fit 
conformational change destabilizes bonds in substrate, lowering Ea
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conformational change destabilizes bonds in substrate, lowering Ea
substrate is converted to product at accelerated rate 
Full
formation of enzyme-substrate complex according to enzyme-substrate specificity
active site undergoes conformational change upon binding for induced fit 
conformational change destabilizes bonds in substrate, lowering Ea
substrate is converted to product at accelerated rate 

Tags: 8_1_metabolism

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