Janus kinases (JAKs) are enzymes of the JAK–STAT intracellular signaling pathways that link many cytokine receptors with gene transcription in the nucleus. The kinases phosphorylate STAT proteins in the cytosol, which then move to the nucleus and activate a variety of genes.
Las Janus quinasas (JAK) son enzimas de las vías de señalización intracelular JAK-STAT que enlazan muchos receptores de citoquinas con la transcripción de genes en el núcleo. Las quinasas fosforilan proteínas STAT en el citosol, que luego se mueven al núcleo y activan una variedad de genes.
| Front | Enzymes of the JAK–STAT intracellular signaling pathways that link many cytokine receptors with gene transcription in the nucleus. The kinases phosphorylate STAT proteins in the cytosol, which then move to the nucleus and activate a variety of genes |
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| Back | Janus kinase JAK family |
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