X-linked agammaglobulinemia (XLA) is a genetic disorder where B-cell development arrests at the pre-B-cell stage, preventing mature B cell and antibody formation due to a defect in the Btk tyrosine kinase.
La agammaglobulinemia ligada al cromosoma X (XLA) es un trastorno genético donde el desarrollo de células B se detiene en la etapa pre-B, impidiendo la formación de células B maduras y anticuerpos debido a un defecto en la tirosina quinasa Btk.
| Front | A genetic disorder in which B-cell development is arrested at the pre-B-cell stage and no mature B cells or antibodies are formed. The disease is due to a defect in the gene encoding the protein tyrosine kinase Btk, which is encoded on the X chromosome |
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| Back | X-linked agammaglobulinemia XLA |
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