Immunoreceptor tyrosine-based inhibition motif (ITIM) are sequence motifs in the signaling chains of inhibitory receptors that are sites of tyrosine phosphorylation, leading to inhibitory signaling, such as through recruitment of phosphatases that remove phosphate groups added by tyrosine kinases.
El motivo de inhibición de tirosina basado en inmunoreceptores (ITIM) son motivos de secuenciación en las cadenas de señalización de receptores inhibidores que son sitios de fosforilación de tirosina, lo que lleva a la señalización inhibitoria, como a través del reclutamiento de fosfatasas que eliminan grupos fosfato añadidos por las tirosina quinasas.
| Front | Sequence motifs in the signaling chains of inhibitory receptors that are sites of tyrosine phosphorylation, leading to inhibitory signaling, such as through recruitment of phosphatases that remove phosphate groups added by tyrosine kinases |
|---|---|
| Back | immunoreceptor tyrosine-based inhibition motif ITIM |
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