Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and isotype switching by deaminating DNA at cytosine residues in immunoglobulin regions; its loss leads to Hyper IgM syndrome and impaired affinity maturation.
Enzyme that initiates somatic hypermutation and isotype switching by deaminating DNA directly at cytosine in immunoglobulin V regions or switch regions. Loss of this enzyme’s activity in patients leads to loss of both activities, causing hyper IgM and lack of affinity maturation
| Front | Enzyme that initiates somatic hypermutation and isotype switching by deaminating DNA directly at cytosine in immunoglobulin V regions or switch regions. Loss of this enzyme’s activity in patients leads to loss of both activities, causing hyper IgM and lack of affinity maturation |
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| Back | activation-induced cytidine deaminase AID |
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