SCIDS (Severe Combined Immunodeficiency Syndrome) occurs because children lack the enzyme ADA, crucial for T and B cell maturation, leading to life-threatening infections. Treatment involves infecting bone marrow stem cells with a retrovirus carrying the normal gene for ADA and returning them to the patient.
SCIDS: Kinder fehlt ein Enzym ADA (Adenosindeaminase), das an der *Reifung* von T- und B-Zellen beteiligt ist. Risiko lebensbedrohlicher Infektionen. Knochenmarkstammzellen werden aus dem Blut entfernt und mit einem *Retrovirus* (RNA) infiziert, das ein normales Gen für das Enzym trägt, und die Zellen werden dem Patienten zurückgegeben.
| Front | SCIDS cause symptoms treatment |
|---|---|
| Back | Severe Combined Immunodeficiency Syndrome Children lack an enzyme ADA (Adenosine Deaminase) that is involved in the *maturation* of T and B cells Risk of life threatening infections *Bone marrow stem cells* are removed from the blood and infected with a *retrovirus* (RNA) that carries a normal gene for the enzyme and the cells are returned to the patient |
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