Non-competitive inhibitors bind to an allosteric site, changing the enzyme's tertiary structure and rendering the active site non-complementary to the substrate, an effect not overcome by substrate or enzyme concentration.
Non-competitive inhibitors bind to an allosteric site, changing the enzyme's tertiary structure and rendering the active site non-complementary to the substrate, an effect not overcome by substrate or enzyme concentration.
| Front | Non competitive inhibitors 2.1.4(f) |
|---|---|
| Back | - bind to allosteric site on enzyme - this changes tertiary structure so it’s no longer complementary - called non competitive as it doesn’t compete with substrate for active site - concentrations of E or S don’t overcome its affect |
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