In a resting neuron, stretch-mediated Na+ channels are narrow, preventing Na+ entry. Pressure deforms the Pacinian corpuscle, stretching its membranes, widening these channels, allowing Na+ influx, and creating an action potential.
في حالة الهدوء للعصبون، تكون قنوات الصوديوم المعتمدة على التمدد ضيقة، مما يمنع دخول الصوديوم. يؤدي الضغط إلى تغيير شكل جسيم باتشيني، وتمدد غشائه، مما يوسع قنوات الصوديوم ويسمح بدخولها، مسببًا جهد الفعل.
| Front | receptors converting stimuli into impulse in mechanoreceptors |
|---|---|
| Back | How mechanoreceptor converts stimuli into impulse/action potential - at resting state, the stretch mediated Na+ channels too narrow for Na+ to enter, so neurone at resting potential - pressure changes shape of pacinian corpuscle, stretching the membranes surrounding the neurone, and so the stretch mediated Na+ channels widen and Na+ can diffuse in - infux of Na+ changes potential of membrane (depolarised), creating a generator potential, which creates an action potential (electrical impulse) |
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