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 Chromosome B Amyloid Protein Parietal Cerebral Genetic Components Alzheimer's

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Genetic components of Alzheimer's disease:

presenilin - chromosome 1 and 14
apolipoprotein E -  chromosome 19
B-amyloid precursor protein -  chromosome 21 
Higher risk in down syndrome
Reduced Choline acetyltransferase(ChAT)/acetylcholine/metabolism in temporal & parietal lobes/blood flow to parietal lobe::correlated to cognitive decline
Diffuse Atrophy of brain on CT or MRI
Flattened sulci in cerebral cortex
Enlarged cerebral ventricles
senile plaques of B-amyloid
Neurofibrillary tangles of hyperphosphorylated tau protein

Tags: behavioral_sciences+_7

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