| Text | Genetic components of Alzheimer's disease: presenilin - chromosome 1 and 14 apolipoprotein E - chromosome 19 B-amyloid precursor protein - chromosome 21 Higher risk in down syndrome Reduced Choline acetyltransferase(ChAT)/acetylcholine/metabolism in temporal & parietal lobes/blood flow to parietal lobe::correlated to cognitive decline Diffuse Atrophy of brain on CT or MRI Flattened sulci in cerebral cortex Enlarged cerebral ventricles senile plaques of B-amyloid Neurofibrillary tangles of hyperphosphorylated tau protein |
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Tags: behavioral_sciences+_7
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